And priapism is a painful erection that lasts more than 6 hours.
| Parameter | Value | Description | Notes |
|---|---|---|---|
| Absorption Time | 30-60 minutes | Time to reach peak plasma concentration | After oral intake |
| Half-life | 17.5 hours | Duration of action | Prolonged effects possible |
| Peak Plasma Levels | Achieved in 2 hours | Time to maximum concentration | Variable per individual |
| Bioavailability | ~84% | Proportion absorbed into bloodstream | When taken with food |
Both conditions are considered emergencies and need to be treated right away to prevent long-term damage. So if you’ve had prolonged erections or priapism in the past, tell your doctor before you take Cialis. They may have you carefully monitor your condition after taking Cialis. Blood cell problems can cialis 2 5 mg include sickle cell anemia and blood cancers such as multiple myeloma or leukemia. If you have a blood cell problem, tell your doctor before taking Cialis. You may be at an increased risk for developing a long lasting erection when taking the drug.
8.6 Hepatic Impairment
Your doctor may recommend a different medication than Cialis. If you have retinitis pigmentosa (a genetic eye condition that may cause vision loss), you should not take Cialis. It’s possible that Cialis may increase your risk of bleeding. So if you have a history of stomach ulcers, taking Cialis may increase your risk of developing bleeding ulcers. (Stomach ulcers are sores in the lining of your stomach or intestine, and they may bleed.) Talk with your doctor before taking Cialis if you have a history of stomach ulcers.
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Cialis may increase your risk of bleeding. If you have a history of bleeding problems, such as hemophilia, taking Cialis may further increase your risk for bleeding. Talk with your doctor before taking Cialis if you have a history of bleeding problems. If you have a deformed penis or a history of Peyronie’s disease (a curved penis), tell your doctor before taking Cialis. You may be at an increased risk for developing a long-lasting erection if you take the drug. Erections lasting longer than 4 hours can be dangerous and may cause permanent damage. Your doctor may recommend a low dose of Cialis if you have blood cell problems. If you’ve had an allergic reaction to Cialis or any of its ingredients, you should not take Cialis.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Cialis Generic | 2.5mg | 270 + 10 Pills | 199.64€ 190.13€ | |
| Cialis Generic | 20mg | 120 + 8 Pills | 188.15€ 179.19€ | |
| Cialis Super Active | 20mg | 180 + 20 Pills | 521.59€ 496.75€ | |
| Cialis Professional | 40mg | 10 Pills | 65.09€ 61.99€ | |
| Cialis Original | 20mg | 48 + 4 Pills | 224.69€ 213.99€ | |
| Cialis Soft Tabs | 20mg | 30 + 4 Pills | 87.43€ 83.27€ | |
| Cialis Generic | 60mg | 360 + 10 Pills | 570.52€ 543.35€ | |
| Cialis Generic | 60mg | 270 + 10 Pills | 443.96€ 422.82€ | |
| Cialis Black | 80mg | 360 + 20 Pills | 639.78€ 609.31€ | |
| Cialis Generic | 40mg | 360 + 10 Pills | 477.87€ 455.11€ |
Ask your doctor what other medications are better options for you. It’s not known if Cialis is safe to take during pregnancy. For more information, please see the “Cialis and pregnancy” section above. It’s not known if Cialis is safe to take while breastfeeding.
12.2 Pharmacodynamics
If you have questions about Cialis and breastfeeding, talk with your doctor. Before taking Cialis, talk with your doctor about your health history. Cialis may not be right for you if you have certain medical conditions or other factors affecting your health. Sexual activity has an impact on your heart function. So if you have a history of heart problems, such as heart attack or an irregular heart rhythm, talk with your doctor before taking Cialis.
Study design
They’ll be able to tell you if your heart is healthy enough for you to have sex. And if you have symptoms such as chest pain or an irregular heartbeat while taking Cialis, you should stop any sexual activity and see a doctor as soon as possible. If you have pulmonary hypertension (a type of high blood pressure in your lungs), talk with your doctor before taking Cialis. In some cases, you may be taking a medication called riociguat (Adempas) to treat your pulmonary hypertension. And taking this medication along with Cialis may cause your blood pressure to become dangerously low.
Dosage for erectile dysfunction (ED)
You should not take Cialis if you’re taking riociguat for pulmonary hypertension. Cialis can cause both high blood pressure and low blood pressure. So if you already have either of these conditions, Cialis may make it worse. If you have a history of blood pressure problems, tell your doctor before you take Cialis. During your treatment, they may have you monitor your blood pressure more often to make sure it doesn’t become too high or too low. For more information, please see the “Cialis and breastfeeding” section above. Note: For more information about the potential negative effects of Cialis, see the “Cialis side effects” section above.
- Patient counseling points: Take exactly as prescribed by your doctor.
- For on-demand (20mg), take at least 30 minutes before sexual activity.
- For daily use, take at approximately the same time each day, with or without food.
- Do not take more than one dose per day.
- Seek immediate medical help for an erection lasting more than 4 hours.
- Stop taking Cialis and seek medical help if you experience sudden vision or hearing loss.
- Be cautious when rising from a sitting/lying position to avoid dizziness.
- Report any new medications (prescription, OTC, herbal) to your doctor before taking Cialis.
- It does not protect against sexually transmitted infections (STIs) or pregnancy.
- Keep all appointments with your doctor for monitoring.
- Do not share your medication with others.
Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication.
| Country | Average Price | Price Range | Purchase Options |
|---|---|---|---|
| USA | $30 | $25 - $40 | Pharmacy, Online pharmacies |
| UK | £25 | £20 - £30 | Local pharmacy, Online stores |
| Canada | CAD 40 | CAD 35 - CAD 50 | Prescription or online sources |
| Australia | AUD 45 | AUD 40 - AUD 55 | Pharmacies, online telemedicine |
The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
- Mechanism of action: Inhibits phosphodiesterase type 5 (PDE5) in smooth muscle.
- PDE5 breaks down cyclic guanosine monophosphate (cGMP).
- Sexual stimulation releases nitric oxide (NO), which increases cGMP.
- cGMP causes smooth muscle relaxation in the corpus cavernosum of the penis.
- This relaxation allows increased blood flow and an erection.
- By inhibiting PDE5, tadalafil increases cGMP levels, enhancing the erectile response.
- In BPH/urinary tract, relaxation of prostate and bladder smooth muscle improves symptoms.
- In PAH, vasodilation occurs in the pulmonary vascular bed.
- It has minimal effect on PDE6 (retina) compared to sildenafil, possibly fewer visual effects.
- It has weak inhibition of PDE11 (function unknown); clinical significance unclear.
- The effect is dependent on sexual stimulation and intact neural pathways.
FDA is alerting consumers and health care professionals that counterfeit versions of Cialis 20 mg tablets were found in the mail on its way to a U.S. consumer. While this shipment was stopped, FDA is concerned about other possible mail shipments to consumers. FDA laboratory analysis showed the counterfeit versions contain multiple active ingredients, which if used could result in adverse effects or harm. Consumers should only buy prescription medicines from state-licensed pharmacies located in the U.S. FDA cannot confirm that the manufacturing, quality, storage, and handling of these products follow U.S. standards because these products are from an unknown source.
Warnings & Precautions
Cialis may increase your risk of stroke, especially if you have a history of stroke. In studies done after Cialis was approved, some people with a history of heart problems had strokes during Cialis treatment. If you have a history of stroke, be sure to talk with your doctor before taking Cialis. They’ll be able to determine whether the medication is safe for you. If you have a history of liver problems, such as hepatitis or liver failure, your body may not break down Cialis quickly enough.
Food effect
This means that the drug can build up in your system, which may increase your risk of side effects from the medication. If you have liver problems, be sure to talk with your doctor before taking Cialis. They may have you start with a 10mg cialis price low dose. If you have kidney problems, such as chronic kidney disease, your body may not be able to get rid of Cialis as quickly as it should. This means that the medication may build up in your body, which can cause serious side effects.
Erectile dysfunction explained
If you have kidney problems, tell your doctor before you take Cialis. They may have you start with a low dose of the medication. If you have any history of vision loss, talk with your doctor before taking Cialis. This vision loss may include having vision conditions such as non-arteritic anterior ischemic optic neuropathy (NAION). Taking Cialis when you have vision loss may increase your risk of vision side effects. Therefore, these products are considered unsafe and should not be used. FDA also recommends consumers talk to their health care professional about their condition and options for treatment if they received a counterfeit product.
| Patient Group | Recommended Dosage | Timing | Comments |
|---|---|---|---|
| Erectile Dysfunction Patients | 20 mg as needed | 30 minutes before activity | Do not exceed once per day |
| Men on other medications | Consult doctor | Varies | Watch for drug interactions |
| Elderly Men | 20 mg or lower | As directed | Adjust based on tolerability |
| Patients with liver issues | Lower dose advisable | Consult physician | Risk of accumulation |
FDA-approved Cialis tablets made by Eli Lilly contain the active ingredient, tadalafil, and are used for the treatment of erectile dysfunction and other approved indications. Currently, Eli Lilly’s authentic product is considered safe and effective for its intended uses.
- Future and research: Patents for brand Cialis have expired in many markets.
- This has led to the availability of multiple generic tadalafil products.
- Research continues on other potential uses for tadalafil.
- Investigated for use in Raynaud's phenomenon, female sexual arousal disorder.
- Studies on its effect in premature ejaculation have shown mixed results.
- Research into its role in treating lower urinary tract symptoms (LUTS) continues.
- New formulations (e.g., sublingual, topical) are under investigation for faster onset.
- Long-term cardiovascular outcomes in specific populations are still being studied.
- Personalized medicine may one day guide optimal PDE5 inhibitor selection.
- Digital health tools are emerging to support ED diagnosis and treatment adherence.
- Always rely on current, approved prescribing information for medical decisions.
There is no indication that the legitimate supply chain is at risk, therefore consumers can be confident that prescription medicines received through legitimate state-licensed pharmacies located in the U.S. are safe and effective. Counterfeit versions of Cialis can be identified by the following differences on the label of the bottle when compared to the authentic product. lists cialis pastile “AUSTR81137” on the front of the bottle; does not include an NDC number on the front of the bottle, such as “NDC 0002-4462-30” for the 20 mg tablets; does not include the tablet strength in a colored box; has different patterns and colors; it has yellow and darker green designs on the front label; has misspellings; it lists, “CLALIS is a product of: Eli lilly Australia PTY Limited” on the side of the bottle; lists the manufacturer location as “112 Wharf Road, WEST RYDE, NSW 2114” on the side of the bottle; and lists “Lot: AC 066018, Exp: 01SEP17” on the side of the bottle.
- Cialis 20mg provides discreet and effective ED treatment.
- The medication’s long-lasting effects are a major advantage.
- Tadalafil was discovered through research into angina treatments.
- Cialis is often used as a first-line medication for ED.
- The drug’s effectiveness depends on individual health factors.
- Cialis can improve sexual performance and satisfaction.
- It is important to hydrate and avoid alcohol during use.
- Cialis 20mg is a trusted medication with a proven track record.
- Contraindications include certain heart conditions.
- The medication is available only through licensed pharmacies.
- Cialis can be part of a broader sexual health management plan.
- Always keep medical history updated with your doctor.
Consumers should not use products that match one or more of the descriptions above. If you have additional information about these products, you may contact FDA at DrugSupplyChainIntegrity@fda.hhs.gov. To date, FDA is not aware of consumer adverse events related to the use of these counterfeit versions of Cialis. Health care professionals and consumers are encouraged to report adverse events related to the use of any suspect medications to FDA’s MedWatch Adverse Event Reporting program by: Completing and submitting the report online at MedWatch Online Voluntary Reporting Form Downloading and completing the form (PDF - 1.22MB), then submitting it via fax at 1-800-FDA-0178 Consumers who buy prescription medicines online should be careful. Some websites sell medicine that may not be safe to use and may put their health at risk. Go to for more information about the risks, to learn the signs of websites that may sell counterfeit or otherwise unsafe medicines, and how to find legitimate licensed online pharmacies. FDA is committed to protecting public health by working to secure the drug supply chain against counterfeit and unapproved medications that enter the United States through fraudulent sources. Picture of authentic bottle of Eli Lilly’s Cialis 20 mg Tablets sold in the U.S. To characterize tadalafil plasma pharmacokinetics in healthy subjects following single and multiple doses. Noncompartmental parameters were calculated for healthy subjects receiving a single 2.5–20-mg tadalafil dose in 13 clinical pharmacology studies.
6.1 Clinical Studies Experience
Blood may become trapped in the penis and lead to an erection lasting longer than 4 hours, which can be dangerous and cause lasting damage. Your doctor will probably have you take a low dose of Cialis or use the medication with caution. History of erections lasting longer than 4 hours. If you have a history of prolonged erections or priapism, you may be at an increased risk for developing them while taking Cialis. A prolonged erection is one that lasts more than 4 hours.