2021, 11, 442– 451, DOI: 10.1039/D0RA09561CThere is no corresponding record for this reference. Artificial Cells, Nanomedicine, and Biotechnology 2015, 43, 282– 290, DOI: 10.3109/21691401.2014.883401There is no corresponding record for this reference.
| Use Case | Typical Dose | Application Area | Onset of Action | Duration of Effect |
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| Erectile Dysfunction | 10 mg | Penis (integumentary) | 15-30 minutes | Up to 4 hours |
| Pulmonary Hypertension | 10-20 mg | N/A (transdermal) | 20 minutes | 3-6 hours |
| Delayed Onset of Erection | 10 mg | Penile tissue | 10-20 minutes | 2-4 hours |
2010, 99, 2357– 2366, DOI: 10.1002/jps.22004There is no corresponding record for this reference.
Uses / Indications
Find more information on the Altmetric Attention Score and how the score is calculated. References This article references 47 other publications. Journal of Drug Delivery Science and Technology 2020, 55, 101444 DOI: 10.1016/j.jddst.2019.101444There is no corresponding record for this reference. Aging 2006, 1, 403– 414, DOI: 10.2147/ciia.2006.1.4.403There is no corresponding record for this reference. J.
3.1. Fabrication of Sildenafil-Loaded Bilosomes (SDF-BS)
Ther 2019, 26, e520– e526, DOI: 10.1097/MJT.0000000000000766There is no corresponding record for this reference. 2014, 4, 214– 215, DOI: 10.3978/j.issn.2223-4292.2014.06.01There is no corresponding record for this reference. 2015, 61, 181– 192, DOI: 10.4103/0022-3859.159421There is no corresponding record for this reference. BMC Cardiovasc Disord 2017, 17, 177, DOI: 10.1186/s12872-017-0569-3There is no corresponding record for this reference. Children 2023, 10, 270, DOI: 10.3390/children10020270There is no corresponding record for this reference. 2006, 322, 60– 66, DOI: 10.1016/j.ijpharm.2006.05.02725Deformable liposomes and ethosomes: Mechanism of enhanced skin deliveryElsayed, Mustafa M. A.; Abdallah, Ossama Y.; Naggar, Viviane F.; Khalafallah, Nawal M.International Journal of Pharmaceutics (2006), 322 (1-2), 60-66CODEN: IJPHDE; ISSN:0378-5173. Drug Deliv 2018, 15, 122– 133, DOI: 10.2174/1567201814666170224141548There is no corresponding record for this reference. Gels 2022, 8, 235, DOI: 10.3390/gels8040235There is no corresponding record for this reference. J.
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Nanomedicine 2020, 15, 9783– 9798, DOI: 10.2147/IJN.S278688There is no corresponding record sildenafil pick up for this reference.
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What is sildenafil used for?
These metrics are regularly updated to reflect usage leading up to the last few days. Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts. The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Drug Discov Today 2016, 21, 888– 899, DOI: 10.1016/j.drudis.2016.03.013There is no corresponding record for this reference.
- Sildenafil gel is sometimes combined with other topical vasodilators to enhance effect.
- The onset of action generally occurs within 15-30 minutes after application.
- Duration of sildenafil gel effects typically lasts 1-2 hours.
- Side effects can include local burning, redness, or itching at the application site.
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Polymers (Basel) 2023, 15, 677, DOI: 10.3390/polym15030677There is no corresponding record for this reference.
- Sildenafil gel absorption bypasses the digestive system, preventing first-pass metabolism.
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Polymers (Basel) 2022, 14, 4184, DOI: 10.3390/polym14194184There is no corresponding record for this reference.
- Sildenafil gel may have potential cosmetic benefits due to skin moisturizing ingredients.
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AAPS PharmSciTech 2018, 19, 2276– 2287, DOI: 10.1208/s12249-018-1019-yThere is no corresponding record for this reference. 2001, 217, 13– 24, DOI: 10.1016/S0378-5173(01)00576-233Elasticity of vesicles assessed by electron spin resonance, electron microscopy and extrusion measurementsvan den Bergh, B. AAPS PharmSciTech 2021, 22, 269, DOI: 10.1208/s12249-021-02113-8There is no corresponding record for this reference. 2015, 485, 329– 340, DOI: 10.1016/j.ijpharm.2015.03.03335Investigating the potential of employing bilosomes as a novel vesicular carrier for transdermal delivery of tenoxicamAl-Mahallawi, Abdulaziz M.; Abdelbary, Aly A.; Aburahma, Mona H.International Journal of Pharmaceutics (Amsterdam, Netherlands) (2015), 485 (1-2), 329-340CODEN: IJPHDE; ISSN:0378-5173.
Diet & Lifestyle Tips
2001, 14, 101– 114, DOI: 10.1016/S0928-0987(01)00167-118Novel mechanisms and devices to enable successful transdermal drug deliveryBarry, B. W.European Journal of Pharmaceutical Sciences (2001), 14 (2), 101-114CODEN: EPSCED; ISSN:0928-0987. 2003, 29, 1013– 1026, DOI: 10.1081/DDC-120025458There is no corresponding record for this reference. 2009, 1, 15– 26, DOI: 10.5138/ijdd.2009.0975.0215.01002There is no corresponding record for this reference. Journal of Young Pharmacists 2016, 8, 335– 340, DOI: 10.5530/jyp.2016.4.8There is no corresponding record for this reference. 2018, 107, 1237– 1246, DOI: 10.1016/j.xphs.2018.01.00536Surfactant effects on lipid-based vesicles propertiesBnyan, Ruba; Khan, Iftikhar; Ehtezazi, Touraj; Saleem, Imran; Gordon, Sarah; O'Neill, Francis; Roberts, MatthewJournal of Pharmaceutical Sciences (Philadelphia, PA, United States) (2018), 107 (5), 1237-1246CODEN: JPMSAE; ISSN:0022-3549. 2016, 513, 688– 696, DOI: 10.1016/j.ijpharm.2016.10.006There is no corresponding record for this reference. In Pharmaceuticals 2022, 15, 1106, DOI: 10.3390/ph15091106There is no corresponding record for this reference. 2021, 29, 269– 279, DOI: 10.1016/j.jsps.2021.02.003There is no corresponding record for this reference. J.
Brand names
Bile salts have been extensively studied to enhance transepithelial permeability for different marker mols. The mechanism of absorption enhancement by sildenafil oral jelly 100mg lovegra bile salts appears to be complex. The aim of the present article was to review bile salt structure and their application as absorption enhancers and the probable mechanism for increasing permeation based on previous studies. 46Chen, C. N.; Watson, G.; Zhao, L.
What should I do if I miss a dose of sildenafil?
Cyclic guanosine monophosphate signalling pathway in pulmonary arterial hypertension. Vascul Pharmacol 2013, 58, 211– 218, DOI: 10.1016/j.vph.2012.09.001Google ScholarThere is no corresponding record for this reference. Cardiol 2018, 13, 35– 37, DOI: 10.15420/ecr.2017:22:2Google ScholarThere is no corresponding record for this reference. This article is cited by 4 publications. Optimized PEGylated Bilosomes for Oral Delivery of Hesperetin: Formulation and In Vitro Evaluation in Breast Cancer. Nanomedicine 2014, 9, 2005– 2017, DOI: 10.2147/IJN.S60674There is no corresponding record for this reference. AAPS PharmSciTech 2020, 21, 113, DOI: 10.1208/s12249-020-01656-6There is no corresponding record for this reference.
Cited By
The liposome structure was maintained when dispersed in an O/W emulsion. The skin fluxes were less than the HPLC detection limit for all systems, while skin deposition increased 4.5-fold compared with aq. Novel Enhanced Therapeutic Efficacy of Dapoxetine HCl by Nano-Vesicle Transdermal Gel for Treatment of Carrageenan-Induced Rat Paw Edema. AAPS PharmSciTech 2020, 21, 113, DOI: 10.1208/s12249-020-01656-6Google ScholarThere is no corresponding record for this reference. 43Walve, J.
3.6. Preparation of Sildenafil-Loaded Bilosomal Gel
R.; Bakliwal, S.; Rane, B. R.; Pawar, S. P. Transferosomes: A surrogated carrier for transdermal drug delivery system. 2011, 2, 204– 213Google ScholarThere is no corresponding record for this reference. 2011, 2, 204– 213There is no corresponding record for this reference.
4. Conclusions
44Lin, H.; Gebhardt, M.; Bian, S.; Kwon, K. A.; Shim, C. K.; Chung, S. J.; Kim, D. D.
License Summary*
Enhancing effect of surfactants on fexofenadine.HCl transport across the human nasal epithelial cell monolayer. 2007, 330, 23– 31, DOI: 10.1016/j.ijpharm.2006.08.043Google ScholarThere is no corresponding record for this reference. 45Moghimipour, E.; Ameri, A.; Handali, S. Absorption-Enhancing Effects of Bile Salts. properties of bile salts are lipid transport by solubilization and transport of some drugs through hydrophobic barriers. 2007, 330, 23– 31, DOI: 10.1016/j.ijpharm.2006.08.043There is no corresponding record for this reference.
What should I do if I forget a dose?
2002, 53 (Suppl 1), 5S– 12S, DOI: 10.1046/j.0306-5251.2001.00027.xThere is no corresponding record for this reference. Pharmaceutics 2020, 12, 1124, DOI: 10.3390/pharmaceutics12111124There is no corresponding record for this reference. Colloids Surf., B 2021, 205, 111868 DOI: 10.1016/j.colsurfb.2021.111868There is no corresponding record for this reference. Ther Deliv 2010, 1, 109– 131, DOI: 10.4155/tde.10.1611Challenges and opportunities in dermal/transdermal deliveryPaudel, Kalpana S.; Milewski, Mikolaj; Swadley, Courtney L.; Brogden, Nicole K.; Ghosh, Priyanka; Stinchcomb, Audra L.Therapeutic Delivery (2010), 1 (1), 109-131CODEN: TDHEA7; ISSN:2041-5990. Skin Research and Technology 2008, 14, 249– 260, DOI: 10.1111/j.1600-0846.2008.00316.xThere is no corresponding record for this reference.
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2013, 30, 1099– 1109, DOI: 10.1007/s11095-012-0946-7There is no corresponding record for this reference. 2012, 80, 1– 28, DOI: 10.3797/scipharm.1108-20There is no corresponding record for this reference. 2004, 56, 659– 674, DOI: 10.1016/j.addr.2003.10.02715Skin electroporation for transdermal and topical deliveryDenet, Anne-Rose; Vanbever, Rita; Preat, VeroniqueAdvanced Drug Delivery Reviews (2004), 56 (5), 659-674CODEN: ADDREP; ISSN:0169-409X. 2008, 60, 1218– 1223, DOI: 10.1016/j.addr.2008.03.006There is no corresponding record for this reference. 2003, 23, 763– 793, DOI: 10.1002/med.10048There is no corresponding record for this reference. Vascul Pharmacol 2013, 58, 211– 218, DOI: 10.1016/j.vph.2012.09.001There is no corresponding record for this reference.
| Drug Class | Examples | Effect | Recommendation |
|---|---|---|---|
| Nitroglycerin | Nitroglycerin | Severe hypotension | Avoid concomitant use |
| Alpha-blockers | Doxazosin, Tamsulosin | Enhanced blood pressure lowering | Use with caution |
| CYP3A4 inhibitors | Ketoconazole, Erythromycin | Increased sildenafil plasma levels | Dose adjustment may be necessary |
| Other PDE5 inhibitors | Tadalafil, Vardenafil | Additive effect and increased risk of side effects | Avoid combining |
Cardiol 2018, 13, 35– 37, DOI: 10.15420/ecr.2017:22:2There is no corresponding record for this reference. Supporting Information Supporting Information The Supporting Information is available free of charge at Impact of formulation variables (A) SPC amount; (B) Span 60 amount; and (C) SDC amount on the in vitro SDF release from various bilosomal formulations; regression analysis of Y1 according to different polynomial models; results of statistical analysis for Y1 response according to the quadratic model; regression analysis of Y2 according to different polynomial models; results of statistical analysis for Y2 response according to the quadratic model; and stability study results of SDF-BS stored at 4 °C for 90 days (PDF) Terms & Conditions Most sildenafil 50mg tablet electronic Supporting Information files are available without a subscription to ACS Web Editions.
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