carbamazepinecarbamazepine will decrease the level ed gels or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. carbamazepine will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. ceritinib and vardenafil both increase QTc interval. clarithromycinclarithromycin and vardenafil both increase QTc interval. clarithromycin and vardenafil both increase QTc interval. danazoldanazol will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. danazol will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. doxazosinvardenafil increases effects of doxazosin by pharmacodynamic synergism. vardenafil increases effects of doxazosin by pharmacodynamic synergism.
Dosing & Uses
[Vardenafil for the treatment of men with erectile dysfunction after radical retropubic prostatectomy]. 2005 Jan;11(1):76-9. Review. 18: Eardley I. Vardenafil: a new oral treatment for erectile dysfunction.
Report Problems to the Food and Drug Administration
2004 Aug;58(8):801-6. Review. 19: Markou S, Perimenis P, Gyftopoulos K, Athanasopoulos A, Barbalias G. Vardenafil (Levitra) for erectile dysfunction: a systematic review and meta-analysis of clinical trial reports. 2004 Dec;16(6):470-8.
ED Prescriptions for $1-2 Per Pill
Review. 20: Bischoff E. Vardenafil preclinical trial data: potency, pharmacodynamics, pharmacokinetics, and adverse events. 10 mg PO ~1 hour before sexual activity; may be increased to 20 mg or reduced to 5 mg, depending on effectiveness and tolerance; not to exceed 1 dose/day TabletKetoconazole 200 mg/day or itraconazole 200 mg/day: Vardenafil dosage not to exceed 5 mg/dayIndinavir, saquinavir, atazanavir, clarithromycin, ketoconazole 400 mg/day or itraconazole 400 mg/day: Vardenafil dosage not to exceed 2.5 mg/dayRitonavir (600 mg q12hr) or cobicistat: Vardenafil dosage not to exceed 2.5 mg/72 hrErythromycin 500 mg q8hr: Vardenafil dosage not to exceed 5 mg/day Ketoconazole 200 mg/day or itraconazole 200 mg/day: Vardenafil dosage not to exceed 5 mg/day Indinavir, saquinavir, atazanavir, clarithromycin, ketoconazole 400 mg/day or itraconazole 400 mg/day: Vardenafil dosage not to exceed 2.5 mg/day Ritonavir (600 mg q12hr) or cobicistat: Vardenafil dosage not to exceed 2.5 mg/72 hr Erythromycin 500 mg q8hr: Vardenafil dosage not to exceed 5 mg/day Oral disintegrating tablet (ODT)Strong or moderate CYP3A4 inhibitors: Do not use (unable to adjust vardenafil dose) Strong or moderate CYP3A4 inhibitors: Do not use (unable to adjust vardenafil dose) Only initiate vardenafil if stabilized on alpha-blocker Stabilized on alpha-blocker therapy (eg, alfuzosin, terazosin, tamsulosin): 5 mg/day PO initially Stabilized on alpha-blocker therapy and taking moderate-to-strong CYP3A4 inhibitor: 2.5 mg/day PO initially Consider time interval between dosing when vardenafil is concomitantly used with alpha-blocker therapy Mild-to-severe: No dosage adjustment necessary Mild (Child-Pugh A): No dosage adjustment necessary Moderate (Child-Pugh B): Start 5mg PO ~1 hr before sexual activity; not to exceed 10 mg once daily Severe (Child-Pugh C): Do not use Mild (Child-Pugh A): No dosage adjustment necessary Moderate-to-severe (Child-Pugh B or C): Do not use Orphan designation for treatment of pulmonary arterial hypertension Respira Therapeutics, Inc; 5901 Indian School Road NE, suite 107; Albuquerque, New Mexico 87110 Film-coated tablet: 10 mg PO ~1 hour before sexual activity; may be increased to 20 mg or reduced to 5 mg, depending on effectiveness and tolerance; not to exceed 1 dose/day Orally disintegrating tablet (ODT): 10 mg PO placed on tongue ~1 hour before sexual activity; not to exceed 1 dose/day; not interchangeable with 10-mg film-coated tablet; if higher or lower doses required, film-coated tablet should be prescribed AUC and Cmax increased by 39% and 21%, respectively, in elderly men (compared with men <45 years) lefamulinlefamulin will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Lefamulin is contraindicated with CYP3A substrates know to prolong the QT interval. entrectinib and vardenafil both increase QTc interval. eribulin and vardenafil both increase QTc interval. Avoid coadministration of fexinidazole with drugs known to block potassium channels and/or prolong QT interval. givinostatvardenafil and givinostat both increase QTc interval. If unable to avoid coadministration, obtain ECGs when initiating, during concomitant use, and as clinically indicated. Withhold if QTc interval >500 ms or a change from baseline >60 ms. vardenafil and givinostat both increase QTc interval.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Levitra Generic | 10mg | 90 + 8 Pills | 150.58€ 143.41€ | |
| Levitra Generic | 20mg | 20 Pills | 52.63€ 50.12€ | |
| Cialis Black | 80mg | 360 + 20 Pills | 639.78€ 609.31€ | |
| Kamagra | 100mg | 120 + 6 Pills | 330.74€ 314.99€ | |
| Viagra Generic | 200mg | 90 + 6 Pills | 170.79€ 162.66€ | |
| Viagra Generic | 200mg | 120 + 8 Pills | 204.80€ 195.05€ | |
| Viagra Generic | 50mg | 180 + 8 Pills | 158.82€ 151.26€ | |
| Kamagra | 100mg | 60 + 4 Pills | 201.34€ 191.75€ | |
| Priligy Generic Dapoxetine | 60mg | 180 + 10 Pills | 494.76€ 471.20€ | |
| Kamagra Oral Jelly | 100mg | 30 + 5 Sachets | 136.20€ 129.71€ | |
| Priligy Generic Dapoxetine | 60mg | 10 Pills | 47.63€ 45.36€ | |
| Cialis Generic | 2.5mg | 20 Pills | 40.73€ 38.79€ | |
| Kamagra Polo | 100 mg | 180 + 8 Pills | 446.52€ 425.26€ | |
| Cialis Generic | 5mg | 90 + 6 Pills | 115.91€ 110.39€ | |
| Kamagra Soft Tabs | 100 mg | 12 Pills | 57.55€ 54.81€ | |
| Cialis Professional | 20mg | 270 + 6 Pills | 623.07€ 593.40€ |
hydroxychloroquine sulfate and vardenafil both increase QTc interval. idelalisibidelalisib will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
What happens if I miss a dose?
amisulpride and vardenafil both increase QTc interval. anagrelide and vardenafil both increase QTc interval. apalutamideapalutamide will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. Avoid or substitute another drug for these medications when possible.
Pregnancy and breastfeeding
Evaluate for loss of therapeutic effect if medication must be coadministered. Adjust dose according to prescribing information if needed. apalutamide will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. artemether and vardenafil both increase QTc interval. asenapineasenapine and vardenafil both increase QTc interval.
Are vardenafil and tadalafil available over the counter?
asenapine and vardenafil both increase QTc interval. asenapine transdermalasenapine transdermal and vardenafil both increase QTc interval. asenapine transdermal and vardenafil both increase QTc interval. Either increases effects of the other by Other (see comment). Comment: Avoid combination; duplicate therapy is not recommended. Idelalisib is a strong CYP3A inhibitor; avoid coadministration with sensitive CYP3A substrates idelalisib will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Idelalisib is a strong CYP3A inhibitor; avoid coadministration with sensitive CYP3A substrates iloperidonevardenafil and iloperidone both increase QTc interval. isoflurane and vardenafil both increase QTc interval. itraconazoleitraconazole and vardenafil both increase QTc interval.
| Parameter | Value | Notes |
|---|---|---|
| Absorption Rate | Fast | Peak plasma concentration in ~1 hour |
| Bioavailability | Approximately 15% | Due to first-pass metabolism |
| Half-Life | About 4-5 hours | Time for plasma levels to reduce by half |
| Metabolism | Primarily hepatic via CYP3A4 | Liver enzyme responsible |
itraconazole and vardenafil both increase QTc interval.
Available Strengths & Forms
buprenorphine subdermal implant and vardenafil both increase QTc interval. buprenorphine transdermalbuprenorphine transdermal and vardenafil both increase QTc interval. buprenorphine transdermal and vardenafil both increase QTc interval. buprenorphine, long-acting injectionbuprenorphine, long-acting injection and vardenafil both increase QTc interval. buprenorphine, long-acting injection and vardenafil both increase QTc interval. Avoid coadministration of QTc prolonging drugs with ivosidenib or replace with alternate therapies. Avoid coadministration of sensitive CYP3A4 substrates with ivosidenib or replace with alternative therapies. If coadministration is unavoidable, monitor patients for loss of therapeutic effect of these drugs.
| Step | Description | Tips |
|---|---|---|
| Taking the medication | Take orally with a glass of water | Can be taken with or without food |
| Timing before sexual activity | 30-60 minutes prior | Avoid heavy fatty meal initially |
| Duration of effect | Up to 4-5 hours, depending on individual | Be aware of your response |
| Do not exceed prescribed dose | Usually 5 mg per dose, once per day | Overdose risks and side effects |
If coadministration of a QTc prolonging drug is unavoidable, monitor for increased risk of QTc interval prolongation.
| Interacting Drug | Effect on Vardenafil 5 mg | Recommendations |
|---|---|---|
| Nitrates | Severe hypotension risk | Avoid concurrent use |
| CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) | Increased Vardenafil levels | Reduce dose or avoid |
| Alpha-blockers | Potential for hypotension | Use with caution, monitor blood pressure |
| Grapefruit juice | Increases drug plasma concentration | Limit intake before dosing |
macimorelinmacimorelin and vardenafil both increase QTc interval. Macimorelin causes an increase of ~11 msec in the corrected QT interval. Avoid coadministration with drugs that prolong QT interval, which could increase risk for developing torsade de pointes-type ventricular tachycardia.
- Vardenafil 5 mg is available in tablet form for oral use.
- It is important to complete the full course unless advised otherwise.
- The medication’s effect can be delayed or reduced by certain foods.
- Regular medical follow-up enhances safe use.
- Patients should inform the doctor of all medications they are taking.
- Its efficacy can be reduced by smoking or excessive alcohol.
- Use with caution in elderly patients due to increased sensitivity.
- Label instructions should be carefully read before use.
- Over-the-counter use without consultation is discouraged.
- Vardenafil 5 mg does not protect against pregnancy or STDs.
- Maintain a healthy weight to improve medication effectiveness.
- Report any allergic reactions like rash or swelling immediately.
Allow sufficient washout time of drugs that are known to prolong the QT interval before administering macimorelin. macimorelin and vardenafil both increase QTc interval.
- Vardenafil 5 mg may be less effective if taken with high-fat meals.
- Side effects like indigestion or muscle aches are possible.
- Inform your doctor about any allergic reactions experienced.
- Be cautious if you have low blood pressure or heart disease.
- It is recommended to avoid taking other ED medications concurrently.
- Regular check-ups help assess medication effectiveness.
- Discontinue use and seek help if adverse reactions occur.
- The medication can improve intimacy confidence and quality.
- Use the lowest effective dose to minimize side effects.
- Vardenafil 5 mg is generally safe when used responsibly.
- Keep out of reach of children and pets.
- Consult your healthcare provider for personalized advice.
mefloquinemefloquine increases toxicity of vardenafil by QTc interval. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents.
Further information
lefamulin will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. nitroglycerin rectalvardenafil increases effects of nitroglycerin rectal by additive vasodilation. Use of nitroglycerin within a few days of PDE5 inhibitors is contraindicated. PDE5 inhibitors have been shown to potentiate the hypotensive effects of organic nitrates. vardenafil increases effects of nitroglycerin rectal by additive vasodilation.
What is the dosage for vardenafil?
Either increases effects of the other by additive vasodilation. Coadministration of PDE-5 inhibitors (eg, avanafil, sildenafil, tadalafil, vardenafil) and guanylate cyclase stimulators (eg, riociguat) is contraindicated due to risk of additive hypotension. Either increases effects of the other by pharmacodynamic synergism. Coadministration of vericiguat with PDE-5 inhibitors may result in additive hypotensive effects. Either increases effects of the other cenforce100 by QTc interval.
Synonym (SY): Vardenafil 5 mg (vardenafil hydrochloride 5.926 mg) Oral Tablet (Atom ID: 3274158)
Each drug prolongs the QTc interval, which may increased the risk of Torsade de pointes, other serious arryhthmias, and sudden death. If coadministration unavoidable, more frequent monitoring is recommended for such patients. alfuzosinvardenafil increases effects of alfuzosin by pharmacodynamic synergism. vardenafil increases effects of alfuzosin by pharmacodynamic synergism. amisulprideamisulpride and vardenafil both increase QTc interval. mefloquine increases toxicity of vardenafil by QTc interval.
Usual Adult Dose for Erectile Dysfunction
buprenorphinebuprenorphine and vardenafil both increase QTc interval. buprenorphine and vardenafil both increase QTc interval. buprenorphine buccalbuprenorphine buccal and vardenafil both increase QTc interval. buprenorphine buccal and vardenafil both increase QTc interval. buprenorphine subdermal implantbuprenorphine subdermal implant and vardenafil both increase QTc interval. vardenafil and milsaperidone both increase QTc interval.
- Vardenafil 5 mg offers a discreet treatment for erectile issues.
- Its onset of action is approximately 30 minutes after ingestion.
- It should be taken about an hour before intimacy.
- Do not crush or break the tablets; swallow whole.
- Patients should discuss health conditions with their doctor first.
- Vardenafil 5 mg is not a cure but manages symptoms.
- Regular use can improve confidence in sexual activity.
- Use caution if you have heart problems or low blood pressure.
- The medication should not be used by women.
- Safety during activities requiring alertness should be assessed.
- Overdose symptoms may include dizziness or chest pain.
- Always adhere to medical advice when using Vardenafil.
moxisylytevardenafil increases effects of moxisylyte by pharmacodynamic synergism. vardenafil increases effects of moxisylyte by pharmacodynamic synergism.